Article

A Pathogenic Deletion in Forkhead Box L1 (FOXL1) Identifies the First Otosclerosis (OTSC) Gene

2021-05-26

Abstract excerpt

<title>Abstract</title> <p>Otosclerosis is a bone disorder of the otic capsule and common form of late-onset hearing impairment. Considered a complex disease, little is known about its pathogenesis. Over the past 20 years, ten autosomal dominant loci (<italic>OTSC1-10</italic>) have been mapped but no genes identified. Herein, we map a new <italic>OTSC</italic> locus to a 9.96 Mb region within the FOX gene cluste...

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Literature Corpus work: 38a6d3ef-850d-57f6-821a-5b89fefbf87d
DOI: 10.21203/rs.3.rs-539887/v1

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