Article

TMEM158-mediated TGF-β signaling pathway modulates the sensitivity of TP53-deficient osteosarcoma to USP14 inhibitors

2025-08-21

Abstract excerpt

<title>Abstract</title> <p>Background Previous studies have demonstrated that the USP14 inhibitor IU1 and USP14/UCHL5 inhibitor b-AP15 can extend the survival period of TP53-deficient mice with spontaneous osteosarcoma (OS). However, the underlying molecular mechanisms remain to be fully elucidated. The transmembrane protein TMEM158 has been identified as a key regulator in the progression of various cancers. Nev...

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Literature Corpus work: 3867e8e6-0cb5-507d-8b67-6d59244ff77d
DOI: 10.21203/rs.3.rs-7071793/v1

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