Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Computational Approach: The Functional Effects of Thyroid Peroxidase Variants in Thyroid Cancer and Genetic Disorders.

JCO clinical cancer informatics - 1 Jan 2024

Sobitan Adebiyi, Gebremedhin Brhan, Yao Qiaobin, Xie Guiqin, Gu Xinbin, Li Jiang, Teng Shaolei

Abstract excerpt

PURPOSE: Thyroid peroxidase (TPO) is essential for the synthesis of thyroid hormones. However, specific mutations render TPO antigenic and prone to autoimmune attacks leading to thyroid cancer, TPO deficiency, and congenital hypothyroidism (CH). Despite technological advancement, most experimental procedures cannot quickly identify the genetic causes of CH nor detect thyroid cancer in the early stages. METHODS:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Congenital Hypothyroidism
Share to Iodide Peroxidase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mass Screening

Share to Mutation

Share to Thyroid Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 38295322
DOI: 10.1200/CCI.23.00140
PMCID: PMC10843385

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Computational Approach: The Functional Effects of Thyroid Peroxidase Variants in Thyroid Cancer and Genetic Disorders.PMID 38295322Read ↗

Screening and Functional Analysis of TPO Gene Mutations in a Cohort of Chinese Patients With Congenital Hypothyroidism.Semantic proximity Read ↗

Genetics and phenomics of hypothyroidism and goiter due to TPO mutations.Semantic proximity Read ↗

Curating the gnomAD database: Report of novel variants in the thyroid peroxidase gene using in silico bioinformatics algorithms and a literature review.Semantic proximity Read ↗

Thyroid Peroxidase Gene Mutations Associated with Thyroid Disorders.Semantic proximity Read ↗

Investigation of the impact of nonsynonymous mutations on thyroid peroxidase dimer.Semantic proximity Read ↗

The Missense Alteration A5T of the Thyroid Peroxidase Gene is Pathogenic and Associated with Mild Congenital Hypothyroidism.Semantic proximity Read ↗

Genetic Screening and Functional Analysis of Thyroid Peroxidase Variants in Chinese Patients with Congenital Hypothyroidism.Semantic proximity Read ↗

Congenital goitrous hypothyroidism: mutation analysis in the thyroid peroxidase gene.Semantic proximity Read ↗

Functional Domain Mapping of TPO: Insights From 6 Variants in Sudanese Kindreds With Congenital Hypothyroidism.Semantic proximity Read ↗

Thyroid Hypoplasia in Congenital Hypothyroidism Associated with Thyroid Peroxidase Mutations.Semantic proximity Read ↗

Functional analysis of thyroid peroxidase gene mutations resulting in congenital hypothyroidism.Semantic proximity Read ↗

Screening and Functional Analysis of TPO Gene Mutations in Patients With Congenital Hypothyroidism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.