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Loss of E2F7 confers resistance to poly-ADP-ribose polymerase (PARP) inhibitors in BRCA2-deficient cells

14 Jul 2018

Abstract excerpt

BRCA proteins are essential for homologous recombination (HR) DNA repair, and their germline or somatic inactivation is frequently observed in human tumors. Understanding the molecular mechanisms underlying the response of BRCA-deficient tumors to chemotherapy is paramount for developing improved personalized cancer therapies. While PARP inhibitors have been recently approved for treatment of BRCA-mutant breast...

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PMID: 30032296
DOI: 10.1093/nar/gky657

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of E2F7 confers resistance to poly-ADP-ribose polymerase (PARP) inhibitors in BRCA2-deficient cellsPMID 30032296Read ↗

Low E2F2 activity is associated with high genomic instability and PARPi resistanceSemantic proximity Read ↗

Amplification of the Mutation-Carrying BRCA2 Allele Promotes RAD51 Loading and PARP Inhibitor Resistance in the Absence of Reversion MutationsSemantic proximity Read ↗

Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130Semantic proximity Read ↗

E2F-7 couples DNA damage-dependent transcription with the DNA repair process.Semantic proximity Read ↗

Genome-wide CRISPR screens reveal cyclin C as synthetic survival target of BRCA2Semantic proximity Read ↗

A Whole-Genome CRISPR Screen Identifies AHR Loss as a Mechanism of Resistance to a PARP7 InhibitorSemantic proximity Read ↗

Elevated PAF1-RAD52 axis confers chemoresistance to human cancersSemantic proximity Read ↗

LARP7 is a BRCA1 ubiquitinase substrate and regulates genome stability and tumorigenesisSemantic proximity Read ↗

Resistance to therapy in BRCA2 mutant cells due to loss of the nucleosome remodeling factor CHD4.Semantic proximity Read ↗

Kub5-Hera RPRD1B Deficiency Promotes "BRCAness" and Vulnerability to PARP Inhibition in BRCA-proficient Breast Cancers.Semantic proximity Read ↗

High-risk human papillomavirus oncogenes disrupt the Fanconi anemia DNA repair pathway by impairing localization and de-ubiquitination of FancD2Semantic proximity Read ↗

RacGAP1 Is a Novel Downstream Effector of E2F7-Dependent Resistance to Doxorubicin and Is Prognostic for Overall Survival in Squamous Cell CarcinomaSemantic proximity Read ↗

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