Article
Clinical relevance of E2F family members in ovarian cancer--an evaluation in a training set of 77 patients.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2007
Reimer Daniel, Sadr Susann, Wiedemair Annemarie, Stadlmann Sylvia, Concin Nicole, Hofstetter Gerda, Müller-Holzner Elisabeth, Marth Christian, Zeimet Alain G
Abstract excerpt
PURPOSE: The major obstacle in treating ovarian cancer is the rapid development of platinum resistance during therapy. Deregulation of members of the E2F family of transcription factors is crucially involved in carcinogenesis and probably in mechanisms underlying platinum resistance. We therefore investigated the relevance of the whole set of E2F family members in predicting clinical outcome and their...
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