Article
Understanding the pathophysiology of severe asthma to generate new therapeutic opportunities.
The Journal of allergy and clinical immunology - 1 Mar 2006
Holgate Stephen T, Holloway John, Wilson Susan, Howarth Peter H, Haitchi Hans Michael, Babu Suresh, Davies Donna E
Abstract excerpt
Although asthma is defined in terms of reversibility of airflow obstruction, as the disease becomes more severe and chronic, it adopts different characteristics, including a degree of fixed airflow obstruction and corticosteroid refractoriness. Underlying these phenotypes is evidence of airway wall remodeling, which should be distinguished from the increase in smooth muscle linked to airways hyperresponsiveness....
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