The airway epithelium: an orchestrator of inflammation, a key structural barrier and a therapeutic target in severe asthma.

Abstract excerpt

Asthma is a disease of heterogeneous pathology, typically characterised by excessive inflammatory and bronchoconstrictor responses to the environment. The clinical expression of the disease is a consequence of the interaction between environmental factors and host factors over time, including genetic susceptibility, immune dysregulation and airway remodelling. As a critical interface between the host and the...

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