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Vitamin D regulates microbiome-dependent cancer immunity

25 Apr 2024

Abstract excerpt

A role for vitamin D in immune modulation and in cancer has been suggested. In this work, we report that mice with increased availability of vitamin D display greater immune-dependent resistance to transplantable cancers and augmented responses to checkpoint blockade immunotherapies. Similarly, in humans, vitamin D–induced genes correlate with improved responses to immune checkpoint inhibitor treatment as well as...

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PMID: 38662827
DOI: 10.1126/science.adh7954

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