Article

Boosting the Sensitivity of Quantitative Single-Cell Proteomics with Activated lon-Tandem Mass Tags (AI-TMT)

2024-02-25

Abstract excerpt

<h4>ABSTRACT</h4> Single-cell proteomics is a powerful approach to precisely profile protein landscapes within individual cells toward a comprehensive understanding of proteomic functions and tissue and cellular states. The inherent challenges associated with limited starting material in single-cell analyses demands heightened analytical sensitivity. Just as advances in sample preparation maximize the amount of m...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 36c49094-e7cc-5798-bb27-233b1d13d594
DOI: 10.1101/2024.02.24.581874

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Boosting the Sensitivity of Quantitative Single-Cell Proteomics with Activated lon-Tandem Mass Tags (AI-TMT)DOI 10.1101/2024.02.24.581874Read

Single Cell Proteomics Using a Trapped Ion Mobility Time-of-Flight Mass Spectrometer Provides Insight into the Post-translational Modification Landscape of Individual Human CellsSemantic proximity Read

Comparative proteome signatures of trace samples by multiplexed Data-Independent AcquisitionSemantic proximity Read

Ultrasensitive single-cell proteomics workflow identifies >1000 protein groups per mammalian cellSemantic proximity Read

Challenging the Astral <sup>™</sup> mass analyzer - up to 5300 proteins per single-cell at unseen quantitative accuracy to study cellular heterogeneitySemantic proximity Read

Global impact of phosphorylation on protein enduranceSemantic proximity Read

SLAPSHOT reveals rapid dynamics of extracellularly exposed proteome in response to calcium-activated plasma membrane phospholipid scramblingSemantic proximity Read

Real-time dynamic single-molecule protein sequencing on an integrated semiconductor deviceSemantic proximity Read

High-density, targeted monitoring of tyrosine phosphorylation reveals activated signaling networks in human tumorsSemantic proximity Read

Development of highly multiplex targeted proteomics assays in biofluids using the Stellar mass spectrometerSemantic proximity Read

Evaluating the capabilities of the Astral mass analyzer for single-cell proteomicsSemantic proximity Read

Sensitive, High-Throughput HLA-I and HLA-II Immunopeptidomics Using Parallel Accumulation-Serial Fragmentation Mass SpectrometrySemantic proximity Read

Increasing the throughput of sensitive proteomics by plexDIASemantic proximity Read