Article
Acute Lung Injury Results from Innate Sensing of Viruses by an ER Stress Pathway
1 Jun 2015
Abstract excerpt
Incursions of new pathogenic viruses into humans from animal reservoirs are occurring with alarming frequency. The molecular underpinnings of immune recognition, host responses, and pathogenesis in this setting are poorly understood. We studied pandemic influenza viruses to determine the mechanism by which increasing glycosylation during evolution of surface proteins facilitates diminished pathogenicity in...
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