Article

P53-dependent bystander cell-killing effect in human cell lines irradiated with carbon ions

2025-06-30

Abstract excerpt

<title>Abstract</title> <p>Since 1994, Phase I/II clinical studies and cancer radiotherapy have used carbon-ion beams at the Heavy Ion Medical Accelerator in Chiba (HIMAC) of the National Institutes for Quantum Science and Technology (QST). Biological effects of direct irradiation for high linear energy transfer (LET) radiation are reported to be higher than those for low-LET X-rays or gamma rays. However, it rem...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 36724f12-09fb-5a9a-8c8a-e79675588baa
DOI: 10.21203/rs.3.rs-6953553/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

P53-dependent bystander cell-killing effect in human cell lines irradiated with carbon ionsDOI 10.21203/rs.3.rs-6953553/v1Read

Heavy‐ion‐induced bystander killing of human lung cancer cells: Role of gap junctional intercellular communicationSemantic proximity Read

Emerging role of radiation induced bystander effects: Cell communications and carcinogenesisSemantic proximity Read

Heavy charged particles produce a bystander effect via cell-cell junctions.Semantic proximity Read

Mechanisms and biological importance of photon-induced bystander responses: do they have an impact on low-dose radiation responsesSemantic proximity Read

Damaging and protective bystander cross-talk between human lung cancer and normal cells after proton microbeam irradiationSemantic proximity Read

Beyond the Target: A Review of Radiation-Induced Bystander Effects in Radiobiology and Radiation TherapySemantic proximity Read

Genetic changes in progeny of bystander human fibroblasts after microbeam irradiation with X-rays, protons or carbon ions: The relevance to cancer riskSemantic proximity Read

Non-targeted effects of photon and particle irradiation and the interaction with the immune systemSemantic proximity Read

Intercellular and intracellular signaling pathways mediating ionizing radiation-induced bystander effects.Semantic proximity Read

Dose response of soft X-ray-induced bystander cell killing affected by p53 status.Semantic proximity Read

Carbon Ion Radiotherapy: A Review of Clinical Experiences and Preclinical Research, with an Emphasis on DNA Damage/RepairSemantic proximity Read

The Radiation Bystander Effect and its Potential Implications for Human HealthSemantic proximity Read