Article

Intra-host quasispecies reconstructions resemble inter-host variability of transmitted chronic hepatitis B virus strains

2023-05-15

Abstract excerpt

The hepatitis B virus is a partially double stranded DNA virus in the Hepadnaviridae family of viruses that infect the liver cells of vertebrates including humans. The virus replicates through the reverse transcription of an RNA intermediate by a viral polymerase, akin to retroviruses. The viral polymerase has high replication capacity but low fidelity and no proofreading activity resulting in a high mutation rate...

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Literature Corpus work: 3656aaf6-d474-5b23-817c-9e3d788b10bd
DOI: 10.1101/2023.05.15.540814

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