Article

HeteroRepur: Efficient Modeling of Heterogeneous Disease Graph for Depression Drug Repurposing using Heterogeneous Graph Neural Networks

2025-01-04

Abstract excerpt

<h4>Objective</h4> Major Depressive Disorder (MDD) is one of the most prevalent psychiatric disorders, yet existing treatments often result in suboptimal responses and encounter high recurrence rate. Repositioning existing medications, which often significantly reduces the required time and budget, has been demonstrated to be a promising strategy for drug discovery of multiple central nervous system (CNS) disorde...

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Literature Corpus work: 3654042f-6db1-5cf4-9e5a-62e276a6d59c
DOI: 10.1101/2024.12.18.629087

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