Article

An autocrine Vitamin D-driven Th1 shutdown program can be exploited for COVID-19

2020-07-19

Abstract excerpt

Pro-inflammatory immune responses are necessary for effective pathogen clearance, but cause severe tissue damage if not shut down in a timely manner 1,2 . Excessive complement and IFN-γ-associated responses are known drivers of immunopathogenesis 3 and are among the most highly induced immune programs in hyper-inflammatory SARS-CoV2 lung infection 4 . The molecular mechanisms that govern orderly shutdown and re...

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Identifiers and source

Literature Corpus work: 3650394b-c1b0-52d8-8329-4c66ef258548
DOI: 10.1101/2020.07.18.210161

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