Article

PGRP-LA regulates peritrophic matrix synthesis and influences trypanosome infection outcomes in tsetse flies

2025-09-12

Abstract excerpt

Peptidoglycan Recognition Proteins (PGRPs) are conserved pattern-recognition receptors that detect microbe-associated molecular patterns (MAMPs) and activate host immune responses. Compared to other dipterans, the tsetse fly ( Glossina morsitans morsitans ) genome encodes only five PGRPs-PGRP-LA, -LB, -LC, -SA, and -SB – far fewer than most dipterans, likely reflecting its sterile blood diet and streamlined micro...

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Literature Corpus work: 35add64e-73c2-5bb3-90eb-0fbaf17617bb
DOI: 10.1101/2025.09.08.674804

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