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The Peritrophic Matrix Mediates Differential Infection Outcomes in the Tsetse Fly Gut following Challenge with Commensal, Pathogenic, and Parasitic Microbes

10 Jun 2014

Abstract excerpt

The insect gut is lined by a protective, chitinous peritrophic matrix (PM) that separates immunoreactive epithelial cells from microbes present within the luminal contents. Tsetse flies (Glossina spp.) imbibe vertebrate blood exclusively and can be exposed to foreign microorganisms during the feeding process. We used RNA interference-based reverse genetics to inhibit the production of a structurally robust PM and...

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PMID: 24913976
DOI: 10.4049/jimmunol.1400163

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