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Leptomeningeal cells induce synaptic failure via Cathepsin B-mediated IL-1β production after Porphyromonas gingivalis infection

2020-11-20

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<title>Abstract</title> <p><bold>Background:</bold> Synaptic failure is the earliest sign before Alzheimer’s disease (AD) onset and closely associated with cognitive decline. Clinical studies have shown that periodontitis is positively correlated with both the onset and progression of AD, and preclinical studies have shown that <italic>Porphyromonas gingivalis </italic>(<italic>P. gingivalis</italic>) and its vir...

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Literature Corpus work
3579239e-b3e4-5149-89f5-9c04fffa0d86
DOI
10.21203/rs.3.rs-111412/v1
Open publication

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Leptomeningeal cells induce&nbsp;synaptic failure via Cathepsin B-mediated IL-1β production after Porphyromonas gingivalis infectionDOI 10.21203/rs.3.rs-111412/v1
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