Article

Expanding kinetoplastid genome annotation through protein structure comparison

2024-08-09

Abstract excerpt

Kinetoplastids belong to the supergroup Discobids, an early divergent eukaryotic clade. Although the amount of genomic information on these parasites has grown substantially, assigning gene functions through traditional sequence-based homology methods remains challenging. Recently, significant advancements have been made in in silico protein structure prediction and algorithms for rapid and precise large-scale pr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 353a8e34-6af8-5a8b-bedc-0a8cce62e809
DOI: 10.1101/2024.08.07.607044

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Expanding kinetoplastid genome annotation through protein structure comparisonDOI 10.1101/2024.08.07.607044Read

TriTrypDB: An integrated functional genomics resource for kinetoplastidaSemantic proximity Read

Host–pathogen protein interactions predicted by comparative modelingSemantic proximity Read

A resource for improved predictions of Trypanosoma and Leishmania protein three-dimensional structureSemantic proximity Read

Phylogenomics of free-living neobodonids reveals they are a paraphyletic group from which all other metakinetoplastids are descendedSemantic proximity Read

GOBASE: an organelle genome database.Semantic proximity Read

Evolutionary Relationships and Protein Domain Architecture in an Expanded Calpain Superfamily in Kinetoplastid ParasitesSemantic proximity Read

Functional annotation hypothetical proteins: a world to be explored in drug development in TrypanosomatidsSemantic proximity Read

FASSO: An AlphaFold based method to assign functional annotations by combining sequence and structure orthologySemantic proximity Read

A resource for improved predictions of <i>Trypanosoma</i> and <i>Leishmania</i> protein three-dimensional structureSemantic proximity Read

Genome-wide subcellular protein map for the flagellate parasite Trypanosoma bruceiSemantic proximity Read

Structure of the mature kinetoplastids mitoribosome and insights into its large subunit biogenesisSemantic proximity Read

Structural and functional studies of the first tripartite protein complex at the <i>Trypanosoma brucei</i> flagellar pocket collarSemantic proximity Read