Article

Deletion of wheat alpha-gliadins from chromosome 6D improves gluten strength and reduces immunodominant celiac disease epitopes

2024-07-23

Abstract excerpt

Wheat gliadins and glutenins confer valuable end-use characteristics but include amino acid sequences (epitopes) that can elicit celiac disease (CeD) in genetically predisposed individuals. The onset of CeD in these individuals is affected by the amount and duration of the exposure to immunogenic epitopes. Therefore, a reduction of epitopes that result in high immune responses in the majority of CeD patients (immu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 351f8c2d-1a25-5b31-8dad-6c882a3b9c60
DOI: 10.1101/2024.07.19.604379

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Deletion of wheat alpha-gliadins from chromosome 6D improves gluten strength and reduces immunodominant celiac disease epitopesDOI 10.1101/2024.07.19.604379Read

A genetic toolkit to reduce wheat immunogenicity and incidence of celiac diseaseSemantic proximity Read

Genome-wide analysis of complex wheat gliadins, the dominant carriers of celiac disease epitopesSemantic proximity Read

Removing celiac disease-related gluten proteins from bread wheat while retaining technological properties: a study with Chinese Spring deletion linesSemantic proximity Read

Production and molecular characterization of bread wheat lines with reduced amount of α-type gliadinsSemantic proximity Read

Unraveling the celiac disease-related immunogenic complexes in a set of wheat and tritordeum genotypes: implications for low-gluten precision breeding in cereal cropsSemantic proximity Read

Dynamic Evolution of α-Gliadin Prolamin Gene Family in Homeologous Genomes of Hexaploid WheatSemantic proximity Read

CRISPR/Cas9 Gene Editing of Gluten in Wheat to Reduce Gluten Content and Exposure—Reviewing Methods to Screen for Coeliac SafetySemantic proximity Read

Analysis of the Gli‐D2 locus identifies a genetic target for simultaneously improving the breadmaking and health‐related traits of common wheatSemantic proximity Read

Alpha-gliadin genes from the A, B, and D genomes of wheat contain different sets of celiac disease epitopesSemantic proximity Read

Outlook for coeliac disease patients: towards bread wheat with hypoimmunogenic gluten by gene editing of α- and γ-gliadin gene familiesSemantic proximity Read

Multiple Wheat Genomes Reveal Novel Gli-2 Sublocus Location and Variation of Celiac Disease Epitopes in Duplicated α-Gliadin GenesSemantic proximity Read

The Gluten Gene: Unlocking the Understanding of Gluten Sensitivity and IntoleranceSemantic proximity Read