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Genome-wide analysis of complex wheat gliadins, the dominant carriers of celiac disease epitopes

16 Mar 2017

Abstract excerpt

Gliadins, specified by six compound chromosomal loci (Gli-A1/B1/D1 and Gli-A2/B2/D2) in hexaploid bread wheat, are the dominant carriers of celiac disease (CD) epitopes. Because of their complexity, genome-wide characterization of gliadins is a strong challenge. Here, we approached this challenge by combining transcriptomic, proteomic and bioinformatic investigations. Through third-generation RNA sequencing,...

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PMID: 28300172
DOI: 10.1038/srep44609

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