Article

Saxiphilin functions as a ‘toxin sponge’ protein that counteracts the effects of saxitoxin poisoning

2025-11-21

Abstract excerpt

Saxitoxin (STX) is among the most potent toxins known, is classified as a chemical weapon, and is the archetype of the paralytic shellfish toxin (PST) family produced by marine and freshwater harmful algal blooms (HAB) 1–3 . STX causes paralysis and death through inhibition of voltage-gated sodium channels (Na V s), has no antidote, and poses a public health and commercial fishing threat due to its accumulation...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 34f63e81-313f-55f0-9399-89224aa0f754
DOI: 10.1101/2025.11.20.689596

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Saxiphilin functions as a ‘toxin sponge’ protein that counteracts the effects of saxitoxin poisoningDOI 10.1101/2025.11.20.689596Read

Evidence that toxin resistance in poison birds and frogs is not rooted in sodium channel mutations and may rely on "toxin sponge" proteins.Semantic proximity Read

Prey-specific toxins provide broad venom activity in cephalopodsSemantic proximity Read

Complementary mechanisms for neurotoxin resistance in a copepod.Semantic proximity Read

Convergent evolution of toxin resistance in animals.Semantic proximity Read

Slowly Making Sense: A Review of the Two-Step Venom System within Slow (Nycticebus spp.) and Pygmy Lorises (Xanthonycticebus spp.).Semantic proximity Read

Multiple mutations in the Nav1.4 sodium channel of New Guinean toxic birds provide autoresistance to deadly batrachotoxin.Semantic proximity Read

Three-fingered RAVERs: Rapid Accumulation of Variations in Exposed Residues of snake venom toxins.Semantic proximity Read

Ancient Diversification of Three-Finger Toxins in Micrurus Coral Snakes.Semantic proximity Read

Sodium channel mutation leading to saxitoxin resistance in clams increases risk of PSP.Semantic proximity Read

Diversification of a single ancestral gene into a successful toxin superfamily in highly venomous Australian funnel-web spiders.Semantic proximity Read

Comparative pharmacology and cloning of two novel arachnid sodium channels: Exploring the adaptive insensitivity of scorpion to its toxins.Semantic proximity Read

Elucidation of the molecular basis of selective recognition uncovers the interaction site for the core domain of scorpion alpha-toxins on sodium channels.Semantic proximity Read