Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sodium channel mutation leading to saxitoxin resistance in clams increases risk of PSP.

Nature - 7 Apr 2005

Bricelj V Monica, Connell Laurie, Konoki Keiichi, Macquarrie Scott P, Scheuer Todd, Catterall William A, Trainer Vera L

Abstract excerpt

Bivalve molluscs, the primary vectors of paralytic shellfish poisoning (PSP) in humans, show marked inter-species variation in their capacity to accumulate PSP toxins (PSTs) which has a neural basis. PSTs cause human fatalities by blocking sodium conductance in nerve fibres. Here we identify a molecular basis for inter-population variation in PSP resistance within a species, consistent with genetic adaptation to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bivalvia
Share to Drug Resistance
Share to Electric Conductivity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Paralysis

Share to Sodium

Share to Sodium Channel Blockers

Share to Sodium Channels

Share to Tetrodotoxin

Source

Identifiers

PMID: 15815630
DOI: 10.1038/nature03415

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sodium channel mutation leading to saxitoxin resistance in clams increases risk of PSP.PMID 15815630Read ↗

Biogeography of resistance to paralytic shellfish toxins in softshell clam, Mya arenaria (L.), populations along the Atlantic coast of North America.Semantic proximity Read ↗

Assessment of sodium channel mutations in Makah tribal members of the U.S. Pacific Northwest as a potential mechanism of resistance to paralytic shellfish poisoning.Semantic proximity Read ↗

Complementary mechanisms for neurotoxin resistance in a copepod.Semantic proximity Read ↗

Evidence that toxin resistance in poison birds and frogs is not rooted in sodium channel mutations and may rely on "toxin sponge" proteins.Semantic proximity Read ↗

Evolutionary diversification of Mesobuthus α-scorpion toxins affecting sodium channels.Semantic proximity Read ↗

Convergent evolution of toxin resistance in animals.Semantic proximity Read ↗

Genetic architecture of a feeding adaptation: garter snake (Thamnophis) resistance to tetrodotoxin bearing prey.Semantic proximity Read ↗

Widespread Evolution of Molecular Resistance to Snake Venom α-Neurotoxins in Vertebrates.Semantic proximity Read ↗

Arizona bark scorpion venom resistance in the pallid bat, Antrozous pallidus.Semantic proximity Read ↗

Not Goanna Get Me: Mutations in the Savannah Monitor Lizard (Varanus exanthematicus) Nicotinic Acetylcholine Receptor Confer Reduced Susceptibility to Sympatric Cobra Venoms.Semantic proximity Read ↗

Multiple origins of pyrethroid insecticide resistance across the species complex of a nontarget aquatic crustacean, Hyalella azteca.Semantic proximity Read ↗

Convergent adaptation to dangerous prey proceeds through the same first-step mutation in the garter snake Thamnophis sirtalis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.