Article

Oral administration of a dual ET <sub>A</sub> /ET <sub>B</sub> receptor antagonist promotes neuroprotection in a rodent model of glaucoma

2020-10-27

Abstract excerpt

<h4>Purpose</h4> Glaucoma is a neurodegenerative disease associated with elevated intraocular pressure and characterized by optic nerve axonal degeneration, cupping of the optic disc and loss of retinal ganglion cells (RGCs). The endothelin (ET) system of vasoactive peptides (ET-1, ET-2, ET-3) and their G-protein coupled receptors (ET A and ET B receptors) have been shown to be contributors to the pathophysiolo...

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Literature Corpus work: 3459e965-fee8-5403-8c59-9f0b549639be
DOI: 10.1101/2020.10.27.357384

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