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Cas9-expressing HC-04 hepatocytes facilitate CRISPR-based analysis of <i>Plasmodium falciparum</i> sporozoite-host interactions

2025-08-19

Abstract excerpt

Sporozoites of Plasmodium falciparum , the deadliest malaria parasite, are transmitted into the skin by infected mosquitoes and migrate to the liver to initiate infection. There, they invade hepatocytes and develop into exoerythrocytic merozoites that, eventually, enter the bloodstream and invade erythrocytes, leading to malaria. The parasite journey involves cell traversal, where sporozoites transiently enter an...

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Literature Corpus work
33b4c51e-0056-5e6c-8332-ca3ae0f97c68
DOI
10.1101/2025.08.19.670452
Open publication

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Cas9-expressing HC-04 hepatocytes facilitate CRISPR-based analysis of <i>Plasmodium falciparum</i> sporozoite-host interactionsDOI 10.1101/2025.08.19.670452
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