Intratumoral CD8+ T cells with a tissue-resident memory phenotype mediate local immunity and immune checkpoint responses in breast cancer.

doi:10.1016/j.ccell.2023.01.004

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Intratumoral CD8+ T cells with a tissue-resident memory phenotype mediate local immunity and immune checkpoint responses in breast cancer.

Cancer cell - 13 Mar 2023

Virassamy Balaji, Caramia Franco, Savas Peter, Sant Sneha, Wang Jianan, Christo Susan N, Byrne Ann, Clarke Kylie, Brown Emmaline, Teo Zhi Ling, von Scheidt Bianca, Freestone David, Gandolfo Luke C, Weber Karsten, Teply-Szymanski Julia, Li Ran, Luen Stephen J, Denkert Carsten, Loibl Sibylle, Lucas Olivia, Swanton Charles, Speed Terence P, Darcy Phillip K, Neeson Paul J, Mackay Laura K, Loi Sherene

Abstract excerpt

CD8+ tumor-infiltrating lymphocytes with a tissue-resident memory T (TRM) cell phenotype are associated with favorable prognosis in patients with triple-negative breast cancer (TNBC). However, the relative contribution of CD8+ TRM cells to anti-tumor immunity and immune checkpoint blockade efficacy in breast cancer remains unknown. Here, we show that intratumoral CD8+ T cells in murine mammary tumors...

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PMID: 36827978
DOI: 10.1016/j.ccell.2023.01.004

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