Article

A novel germline EGFR variant p.R831H causes predisposition to familial CDK12-mutant prostate cancer with tandem duplicator phenotype

2020-02-25

Abstract excerpt

5-10% of total prostate cancer (PCa) cases are hereditary. Particularly, immunocheckpoint inhibitor-sensitive tandem duplicator phenotype (TDP) accounts for 6.9% PCa cases, whereas genetic susceptibility genes remain completely unknown. We identified a Chinese family with two PCa patients, in which the PCa phenotype co-segregated with a rare germline variant EGFR R831H . Patient-derived conditionally reprogrammed...

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Literature Corpus work: 32cfec1b-7f00-5c6f-bf57-bd64a2cd5d85
DOI: 10.1101/2020.02.23.20027045

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