Article
A novel germline EGFR variant p.R831H causes predisposition to familial CDK12-mutant prostate cancer with tandem duplicator phenotype.
Oncogene - 1 Oct 2020
Qian Kaiyu, Wang Gang, Ju Lingao, Liu Jiyan, Luo Yongwen, Wang Yejinpeng, Peng Tianchen, Chen Fangjin, Zhang Yi, Xiao Yu, Wang Xinghuan
Abstract excerpt
5-10% of total prostate cancer (PCa) cases are hereditary. Particularly, immune checkpoint inhibitor-sensitive tandem duplicator phenotype (TDP) accounts for 6.9% of PCa cases, whereas genetic susceptibility genes remain completely unknown. We identified a Chinese family with two PCa patients, in which the PCa phenotype co-segregated with a rare germline variant EGFRR831H. Patient-derived conditionally...
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