Back to search

Article

A comparative network analysis of high-risk MYCN amplified and high-risk MYCN non-amplified neuroblastoma patients

2024-10-29

Abstract excerpt

Neuroblastoma is the most common extracranial solid tumor in children. Under contemporary staging guidelines, amplification of MYCN, defined as possessing 10 or more copies of the MYCN gene, is sufficient to classify a patient as high-risk. We aim to investigate the complex genetic landscape of neuroblastoma through a network biology perspective, focusing on complex protein-protein interaction (PPI) networks. Rean...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
32b12c37-ee8e-5c01-8fd2-abfd98b3d99f
DOI
10.1101/2024.10.24.620136
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A comparative network analysis of high-risk MYCN amplified and high-risk MYCN non-amplified neuroblastoma patientsDOI 10.1101/2024.10.24.620136
Integrative omics reveals MYCN as a global suppressor of cellular signalling and enables network-based therapeutic target discovery in neuroblastomaSemantic proximity
Prognostic significance of MYCN related genes in pediatric neuroblastoma: a study based on TARGET and GEO datasetsSemantic proximity
Prognostic significance of MYCN related genes in pediatric neuroblastoma: a study based on TARGET and GEO datasetsSemantic proximity
Bioinformatic analysis of the inner heterogeneity within MYCN non-amplified pediatric neuroblastoma sub-groupSemantic proximity
Transcript signatures that predict outcome and identify targetable pathways in MYCN-amplified neuroblastoma.Semantic proximity
Dysregulation of Extracellular Matrix Genes Identifies Neuroblastoma Patients at High Risk of Recurrence and Poor Outcome.Semantic proximity
Accumulation of potential driver genes with genomic alterations predicts survival of high-risk neuroblastoma patientsSemantic proximity
Genomic profile of MYCN non-amplified neuroblastoma and potential for immunotherapeutic strategies in neuroblastomaSemantic proximity
Co-expression analysis identifies long noncoding RNA <i>SNHG1</i> as a novel predictor for event-free survival in neuroblastomaSemantic proximity
Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma.Semantic proximity
Unveiling MYCN regulatory networks in neuroblastoma via integrative analysis of heterogeneous genomics dataSemantic proximity
High-risk, Expression-Based Prognostic Long Noncoding RNA Signature in NeuroblastomaSemantic proximity
Select a neighboring publication to make it the new centre.