Dysregulation of Extracellular Matrix Genes Identifies Neuroblastoma Patients at High Risk of Recurrence and Poor Outcome.

Abstract excerpt

BACKGROUND: Neuroblastoma is the most common extracranial solid tumor in children and exhibits substantial clinical heterogeneity. Although key genetic alterations such as N-Myc proto-oncogene protein amplification and anaplastic lymphoma kinase mutations are known drivers of neuroblastoma, their clinical utility is limited by population-specific genetic diversity. To address this, we propose a...

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