Article

Cell-specific delivery of GJB2 restores auditory function in mouse models of DFNB1 deafness and mediates appropriate expression in NHP cochlea

2024-12-24

Abstract excerpt

Mutations in the GJB2 gene cause the most common form of human hereditary hearing loss, known as DFNB1. GJB2 is expressed in two cell groups of the cochlea—epithelial cells of the organ of Corti and fibrocytes of the inner sulcus and lateral wall—but not by sensory hair cells or neurons. Attempts to treat mouse models of DFNB1 with AAV vectors mediating nonspecific Gjb2 expression have not substantially restore...

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Literature Corpus work: 3287fee6-957c-5188-9e81-ae3839e427d7
DOI: 10.1101/2024.12.24.630240

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