Article

Are Granulins Copper Sequestering Proteins?

2020-07-26

Abstract excerpt

Granulins (GRN 1-7) are short (∼6 kDa), cysteine-rich proteins that are generated upon the proteolytic processing of progranulin (PGRN). These modules, along with their precursor, have been implicated in multiple pathophysiological roles, especially in neurodegenerative diseases. Our previous investigations into GRN-3 and GRN-5 reveal them to be fully disordered in the reduced form and implicate redox sensitive at...

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Literature Corpus work: 32313f41-25c3-5a5d-8fb2-01a71fe00f39
DOI: 10.1101/2020.07.24.220665

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