Article

DDX5 (p68) orchestrates β-catenin, RelA and SP1 mediated MGMT gene expression: Implication in TMZ chemoresistance

2023-04-29

Abstract excerpt

DDX5 (p68) upregulation has been linked with various cancers of different origins, especially Colon Adenocarcinomas. Similarly, across cancers, MGMT has been identified as the major contributor of chemoresistance against DNA alkylating agents like Temozolomide (TMZ). TMZ is an emerging potent chemotherapeutic agent across cancers under the arena of drug repurposing. Recent studies have established that patients wi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 31e7da62-ac2c-5e0c-9864-999591bc5e8f
DOI: 10.1101/2023.04.29.538802

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DDX5 (p68) orchestrates β-catenin, RelA and SP1 mediated MGMT gene expression: Implication in TMZ chemoresistanceDOI 10.1101/2023.04.29.538802Read

The DEAD-box protein p68 and β-catenin: the crucial regulators of FOXM1 gene expression in arbitrating colorectal cancerSemantic proximity Read

PRMT6-mediated Transcriptional Activation of YTHDF2 Promotes Glioblastoma Migration, Invasion, and EMT via the Wnt–β-Catenin PathwaySemantic proximity Read

MEN1 Deficiency‐Driven Activation of the β‐Catenin‐MGMT Axis Promotes Pancreatic Neuroendocrine Tumor Growth and Confers Temozolomide ResistanceSemantic proximity Read

MDM4 was associated with poor prognosis and tumor-immune infiltration of cancersSemantic proximity Read

ALTering cancer by triggering telomere replication stress through the stabilization of promoter G-quadruplex in <i>SMARCAL1</i>Semantic proximity Read

NSC666715 and Its Analogs Inhibit Strand-Displacement Activity of DNA Polymerase β and Potentiate Temozolomide-Induced DNA Damage, Senescence and Apoptosis in Colorectal Cancer CellsSemantic proximity Read

Epithelial-Mesenchymal Transition and MicroRNAs in Colorectal Cancer Chemoresistance to FOLFOXSemantic proximity Read

Positive feedback loop of c-myc/XTP6/NDH2/NF-κB to promote malignant progression in glioblastomaSemantic proximity Read

Methyltransferase MGMT upregulation drives metastasis by activating epithelial-mesenchymal transition in KRAS mutant colon cancer.Semantic proximity Read

The dual role of DNA repair protein MGMT in cancer prevention and treatmentSemantic proximity Read

The RNA-binding protein DDX39B promotes colorectal adenocarcinoma progression by stabilizing DCLK1Semantic proximity Read

A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastomaSemantic proximity Read