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RNA-Seq reveals changes in human placental metabolism, transport and endocrinology across the first–second trimester transition

8 Jun 2021

Abstract excerpt

The human placenta is exposed to major environmental changes towards the end of the first trimester associated with full onset of the maternal arterial placental circulation. Changes include a switch from histotrophic to hemotrophic nutrition, and a threefold rise in the intraplacental oxygen concentration. We evaluated their impact on trophoblast development and function using RNA-sequencing (RNA-Seq) and...

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PMID: 34100896
DOI: 10.1242/bio.058222

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