Article

Mesenchymal Stem/Stromal Cells-derived extracellular vesicles as a safer therapeutic strategy in a mild metabolic osteoarthritis model

2022-12-16

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Mesenchymal stromal/stem cells (MSCs) and MSC-derived extracellular vesicles (MSC-EVs) hold promise as a disease modifying treatment in Osteoarthritis (OA). Obesity, and its associated inflammation, contribute to OA development and metabolic OA represents a specific and significant group of the OA patient population. Given their immunomodulatory properties, MSC...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5f3453a7-108b-5931-9f5d-6e68778e6040
DOI: 10.21203/rs.3.rs-2096990/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mesenchymal Stem/Stromal Cells-derived extracellular vesicles as a safer therapeutic strategy in a mild metabolic osteoarthritis modelDOI 10.21203/rs.3.rs-2096990/v1Read

Comprehensive Analysis of Therapeutic Strategies Using Mesenchymal Stem Cell-Derived Exosomes in Preclinical Models of OsteoarthritisSemantic proximity Read

Small extracellular vesicles from mesenchymal stromal cells: the next therapeutic paradigm for musculoskeletal disordersSemantic proximity Read

Extracecellulr vesicles (EVs) microRNAs (miRNAs) derived from mesenchymal stem cells (MSCs) in osteoarthritis (OA); detailed role in pathogenesis and possible therapeuticsSemantic proximity Read

Research progress in the use of mesenchymal stem cells and their derived exosomes in the treatment of osteoarthritisSemantic proximity Read

Increased susceptibility of Trpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet.Semantic proximity Read

Recent advances in the treatment of osteoarthritisSemantic proximity Read

ESC-sEVs alleviate non-early-stage osteoarthritis progression by rejuvenating senescent chondrocytes via FOXO1A-autophagy axis but not inducing apoptosisSemantic proximity Read

Advantages and challenges of stem cell therapy for osteoarthritis (Review)Semantic proximity Read

Astragalus-Angelica sinensis-Derived Extracellular Vesicles Attenuate Knee Osteoarthritis with Periarticular Muscle Atrophy via PPARγ-Mediated Regulation of Skeletal Muscle Fatty Acid MetabolismSemantic proximity Read

Treatment of osteoarthritis with mesenchymal stem cells.Semantic proximity Read

Cell-Free Fat Extract Attenuate Osteoarthritis via Chondrocytes Regeneration and Macrophages ImmunomodulationSemantic proximity Read