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Article

Obesity reprograms adipose extracellular vesicles to induce muscle atrophy via miR-150-5p-mediated transcriptional silencing

2025-12-11

Abstract excerpt

<h4>Background</h4> Sarcopenic obesity, where excess body fat coexists with reduced muscle mass and function, is becoming increasingly common in ageing populations and contributes to poor physical and metabolic health. Although adipose tissue-secreted factors are implicated in muscle decline, the specific mechanisms remain unclear. Extracellular vesicles (EVs), which carry regulatory cargo such as microRNAs (miRN...

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Literature Corpus work
f7b68c23-fd83-5a70-a3c9-e56e19773a4d
DOI
10.64898/2025.12.09.693129
Open publication

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Obesity reprograms adipose extracellular vesicles to induce muscle atrophy via miR-150-5p-mediated transcriptional silencingDOI 10.64898/2025.12.09.693129
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