Article
The bidirectional relationship between CFTR and lipids.
Communications biology - 20 Apr 2020
Cottrill Kirsten A, Farinha Carlos M, McCarty Nael A
Abstract excerpt
Cystic Fibrosis (CF) is the most common life-shortening genetic disease among Caucasians, resulting from mutations in the gene encoding the Cystic Fibrosis Transmembrane conductance Regulator (CFTR). While work to understand this protein has resulted in new treatment strategies, it is important to emphasize that CFTR exists within a complex lipid bilayer - a concept largely overlooked when performing structural...
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