Article
GacA is essential for Group A Streptococcus and defines a new class of monomeric dTDP-4-dehydrorhamnose reductases (RmlD).
Molecular microbiology - 1 Dec 2015
van der Beek Samantha L, Le Breton Yoann, Ferenbach Andrew T, Chapman Robert N, van Aalten Daan M F, Navratilova Iva, Boons Geert-Jan, McIver Kevin S, van Sorge Nina M, Dorfmueller Helge C
Abstract excerpt
The sugar nucleotide dTDP-L-rhamnose is critical for the biosynthesis of the Group A Carbohydrate, the molecular signature and virulence determinant of the human pathogen Group A Streptococcus (GAS). The final step of the four-step dTDP-L-rhamnose biosynthesis pathway is catalyzed by dTDP-4-dehydrorhamnose reductases (RmlD). RmlD from the Gram-negative bacterium Salmonella is the only structurally characterized...
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