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Establishment of<i>in silico</i>prediction of adjuvant chemotherapy response from active mitotic gene signature in non-small cell lung cancer

2025-03-15

Abstract excerpt

Conventional chemotherapeutics exploit cancer’s hallmark of active cell cycling, primarily targeting mitotic cells. Consequently, the mitotic index (MI), representing the proportion of cells in mitosis, serves as both a prognostic biomarker for cancer progression and a predictive marker for chemo-responsiveness. In this study, we developed a transcriptome signature to predict the chemotherapeutic responsiveness ba...

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Identifiers and source

Literature Corpus work
3174c481-1a3f-5e88-83e1-fdd85253ad98
DOI
10.1101/2025.03.14.25322930
Open publication

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Establishment of<i>in silico</i>prediction of adjuvant chemotherapy response from active mitotic gene signature in non-small cell lung cancerDOI 10.1101/2025.03.14.25322930
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