Article

Transcriptomic profiling of cerebrospinal fluid predicts shunt surgery responses in patients with Normal Pressure Hydrocephalus

2022-08-22

Abstract excerpt

Molecular biomarkers for neurodegenerative diseases are critical for advancing diagnosis and therapy. Normal Pressure Hydrocephalus (NPH) is a neurodegenerative disorder characterized by progressive gait impairment, urinary incontinence, and cognitive decline. In contrast to most other neurodegenerative disorders, NPH symptoms can be improved by the placement of a ventricular shunt that drains excess cerebrospinal...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 31731cc9-4467-5471-b602-223027f3f583
DOI: 10.1101/2022.08.20.22279018

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptomic profiling of cerebrospinal fluid predicts shunt surgery responses in patients with Normal Pressure HydrocephalusDOI 10.1101/2022.08.20.22279018Read

Multi-omic analysis elucidates the genetic basis of hydrocephalusSemantic proximity Read

Single-Cell RNA Sequencing of Cerebrospinal Fluid as an Advanced Form of Liquid Biopsy for Neurological DisordersSemantic proximity Read

Navigating the ventricles: Novel insights into the pathogenesis of hydrocephalusSemantic proximity Read

Transcriptional profiling of transport mechanisms and regulatory pathways in rat choroid plexusSemantic proximity Read

Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus.Semantic proximity Read

Cerebrospinal fluid proteome maps detect pathogen-specific host response patterns in meningitisSemantic proximity Read

Relationship between plasma proteome and hydrocephalus: a two-sample Mendelian randomization analysisSemantic proximity Read

Genetic and molecular mechanisms of hydrocephalusSemantic proximity Read

Transcriptome profiling of cerebrospinal fluid in Alzheimer’s Disease reveals molecular dysregulations associated with diseaseSemantic proximity Read

Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluidSemantic proximity Read

Developmental genetic determinants of the human cerebrospinal fluid-ventricular system.Semantic proximity Read

Risk Variants Associated With Normal Pressure Hydrocephalus: Genome-Wide Association Study in the FinnGen Cohort.Semantic proximity Read