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Article

Foxc1 dependent mesenchymal signalling drives embryonic cerebellar growth

16 Dec 2014

Abstract excerpt

Loss of Foxc1 is associated with Dandy-Walker malformation, the most common human cerebellar malformation characterized by cerebellar hypoplasia and an enlarged posterior fossa and fourth ventricle. Although expressed in the mouse posterior fossa mesenchyme, loss of Foxc1 non-autonomously induces a rapid and devastating decrease in embryonic cerebellar ventricular zone radial glial proliferation and concurrent...

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PMID: 25513817
DOI: 10.7554/elife.03962

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