Article

Exploring the Therapeutic Potential of Nicotinamide‐N‐Methyltransferase in Clear Cell Renal Cell Carcinoma

2024-10-01

Abstract excerpt

Clear cell renal cell carcinoma (ccRCC) is a highly aggressive subtype of renal cancer, often associated with poor prognosis and high mortality rates. In this study, we identified Nicotinamide N-methyltransferase (NNMT) as a key gene involved in the pathogenesis of ccRCC through RNA sequencing analysis of tumor and normal tissues from 14 patients. NNMT was among the top five upregulated genes, and its high express...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 30ae2e5e-cb7e-5862-b2f3-8b58bbbe56b1
DOI: 10.20944/preprints202410.0041.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Exploring the Therapeutic Potential of Nicotinamide‐N‐Methyltransferase in Clear Cell Renal Cell CarcinomaDOI 10.20944/preprints202410.0041.v1Read

A proteogenomic analysis of clear cell renal cell carcinoma in a Chinese populationSemantic proximity Read

Clinical significance and oncogenic function of NR1H4 in clear cell renal cell carcinomaSemantic proximity Read

Navigating the Current Landscape of Non-Clear Cell Renal Cell Carcinoma: A Review of the LiteratureSemantic proximity Read

Recent progress in non-clear cell renal cell carcinoma: biology and therapeutic strategiesSemantic proximity Read

Identification and Comprehensive Validation of a DNA Methylation-Driven Gene-Based Prognostic Model for Clear Cell Renal Cell CarcinomaSemantic proximity Read

A Proteogenomic Atlas of Clear Cell Renal Cell Carcinoma in a Chinese PopulationSemantic proximity Read

Comprehensive Analysis of m5C RNA Methylation Regulator Genes in Clear Cell Renal Cell CarcinomaSemantic proximity Read

N7-Methylguanosine-Related lncRNAs: Integrated Analysis Associated With Prognosis and Progression in Clear Cell Renal Cell CarcinomaSemantic proximity Read

Epigenomics of clear cell renal cell carcinoma: mechanisms and potential use in molecular pathology.Semantic proximity Read

A comprehensive investigation discovered the novel methyltransferase METTL24 as one presumably prognostic gene for kidney renal clear cell carcinoma potentially modulating tumor immune microenvironmentSemantic proximity Read

Pan-cancer analysis combined with experiments predicts NNMT as a therapeutic target for human cancersSemantic proximity Read

Notch Pathway Is Activated via Genetic and Epigenetic Alterations and Is a Therapeutic Target in Clear Cell Renal CancerSemantic proximity Read