Article
A new immuno-, dystrophin-deficient model, the NSG-mdx(4Cv) mouse, provides evidence for functional improvement following allogeneic satellite cell transplantation.
Stem cells (Dayton, Ohio) - 1 Aug 2013
Arpke Robert W, Darabi Radbod, Mader Tara L, Zhang Yu, Toyama Akira, Lonetree Cara-Lin, Nash Nardina, Lowe Dawn A, Perlingeiro Rita C R, Kyba Michael
Abstract excerpt
Transplantation of a myogenic cell population into an immunodeficient recipient is an excellent way of assessing the in vivo muscle-generating capacity of that cell population. To facilitate both allogeneic and xenogeneic transplantations of muscle-forming cells in mice, we have developed a novel immunodeficient muscular dystrophy model, the NSG-mdx(4Cv) mouse. The IL2Rg mutation, which is linked to the Dmd gene...
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