Article

Identification and Validation of T Cell Exhaustion Signature for Predicting Prognosis and Immune Response in Pancreatic Cancer by Integrated Analysis of Single-Cell and Bulk RNA Sequencing Data

2024-02-06

Abstract excerpt

<h4>Purpose: </h4> Pancreatic cancer (PAAD) is one of the most lethal malignancies. Immunotherapy is largely ineffective in PAAD. T-cell exhaustion contributes to the resistance for immunotherapies. We investigated the prognostic potential of T cell exhaustion-related genes (TEXGs). <h4>Methods:</h4> Single-cell RNA (scRNA) sequencing dataset from TISCH, and bulk sequencing datasets from TCGA and GTEx were applied...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2fd83c2e-523b-572b-a0b4-f4333830e2d5
DOI: 10.20944/preprints202402.0281.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification and Validation of T Cell Exhaustion Signature for Predicting Prognosis and Immune Response in Pancreatic Cancer by Integrated Analysis of Single-Cell and Bulk RNA Sequencing DataDOI 10.20944/preprints202402.0281.v1Read

Novel Insights into T-Cell Exhaustion and Cancer Biomarkers in PDAC Using ScRNA-SeqSemantic proximity Read

Integration of Single-Cell RNA Sequencing and Bulk RNA Sequencing Reveals That TAM2-Driven Genes Affect Immunotherapeutic Response and Prognosis in Pancreatic CancerSemantic proximity Read

Immune Subtyping for Pancreatic Cancer with Implication in Clinical Outcomes and Improving ImmunotherapySemantic proximity Read

Identification of the CD8+T-cell exhaustion signature of Hepatocellular Carcinoma for the Prediction of prognosis and Immune microenvironment by Integrated Analysis of Bulk- and Single-Cell RNA Sequencing DataSemantic proximity Read

Prioritizing exhausted T cell marker genes highlights immune subtypes in pan-cancerSemantic proximity Read

Pan-cancer landscape of T-cell exhaustion heterogeneity within the tumor microenvironment revealed a progressive roadmap of hierarchical dysfunction associated with prognosis and therapeutic efficacySemantic proximity Read

Comprehensive Genomic Analysis of the Prognostic and Immunological Characteristics of Tertiary Lymphoid structures and CD8+ T-cells in Pancreatic Ductal AdenocarcinomaSemantic proximity Read

Single-cell transcriptomics analysis reveals dynamic changes and prognostic signature in tumor microenvironment of PDACSemantic proximity Read

Comprehensive machine-learning survival framework develop a consensus model in large scale multi-center cohorts for pancreatic cancerSemantic proximity Read

Deciphering the Prognostic Implications of the Components and Signatures in the Immune Microenvironment of Pancreatic Ductal AdenocarcinomaSemantic proximity Read

Prognostic value of eight immune gene signatures in pancreatic cancer patientsSemantic proximity Read

A novel immune checkpoint score system for prognostic evaluation in pancreatic adenocarcinomaSemantic proximity Read