Article

Targeted overexpression of Bcl-2 in ovaries of transgenic mice leads to decreased follicle apoptosis, enhanced folliculogenesis, and increased germ cell tumorigenesis

1996-11-01

Abstract excerpt

We have generated transgenic mice overexpressing Bcl-2, an apoptosis suppression protein, in ovarian cells using the inhibit-alpha gene promoter/enhancer. Ovarian apoptotic DNA fragmentation induced in immature animals by a low dose (2 IU) of PMSG was suppressed by greater than 55% in transgenic mice compared to their wild-type littermates. Morphological and in situ DNA end-labeling analyses showed that granulosa...

Topics

Open a Topic to create a Post that cites this publication.

Reproductive Biology and Fertility

Identifiers and source

Literature Corpus work: 2fb55814-9de2-514a-9085-e36eb949eb3b
DOI: 10.1210/en.137.11.4837

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeted overexpression of Bcl-2 in ovaries of transgenic mice leads to decreased follicle apoptosis, enhanced folliculogenesis, and increased germ cell tumorigenesisDOI 10.1210/en.137.11.4837Read

Targeted overexpression of Bcl-2 in ovaries of transgenic mice leads to decreased follicle apoptosis, enhanced folliculogenesis, and increased germ cell tumorigenesis.Semantic proximity Read

Targeted Expression of Bcl-2 in Mouse Oocytes Inhibits Ovarian Follicle Atresia and Prevents Spontaneous and Chemotherapy-Induced Oocyte Apoptosis In VitroSemantic proximity Read

Impairment of Spermatogenesis in Transgenic Mice With Selective Overexpression of Bcl‐2 in the Somatic Cells of the TestisSemantic proximity Read

Ablation of bcl-2 gene expression decreases the numbers of oocytes and primordial follicles established in the post-natal female mouse gonadSemantic proximity Read

Ovarian follicle development and transgenic mouse models.Semantic proximity Read

Ablation of bcl-2 gene expression decreases the numbers of oocytes and primordial follicles established in the post-natal female mouse gonad.Semantic proximity Read

Differential apoptotic activities of wild-type FOXL2 and the adult-type granulosa cell tumor-associated mutant FOXL2 (C134W).Semantic proximity Read

Production of transgenic mice by random recombination of targeted genes in female germline stem cellsSemantic proximity Read

Regulation of Oocyte Apoptosis: A View from Gene Knockout MiceSemantic proximity Read

Inhibition of testicular germ cell apoptosis and differentiation in mice misexpressing Bcl-2 in spermatogoniaSemantic proximity Read

Programmed Cell Death in the Ovary: Insights and Future Prospects Using Genetic TechnologiesSemantic proximity Read