Article

Upfront Menin-inhibitor resistance in multiply pretreated leukemias

2023-03-16

Abstract excerpt

Inhibitors of the Menin-KMT2A interaction are promising agents for the treatment of KMT2A -rearranged ( KMT2A -r) leukemias. We evaluated Menin inhibition in patient derived xenografts of KMT2A-r leukemias with high-risk features. Three AMLs with high-risk fusion partners ( MLLT10, MLLT4 ) and two infant ALL samples were sensitive to Menin inhibition. We also evaluated serial samples from two patients with mul...

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Literature Corpus work: 960b07b7-ec11-5a6e-b564-ba2fafe2427f
DOI: 10.1101/2023.03.16.532874

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