Collagen modification remodels the sarcoma tumor microenvironment and promotes resistance to immune checkpoint inhibition

Abstract excerpt

Molecular mechanisms underlying immune checkpoint inhibitor (ICI) response heterogeneity in solid tumors, including soft tissue sarcomas (STS), remain poorly understood. Herein, we demonstrate that the collagen-modifying enzyme, procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (Plod2), which is over-expressed in many tumors relative to normal tissues, promotes immune evasion in undifferentiated pleomorphic sarcom...

Topics

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• Cancer Cells and Metastasis
• Cell Adhesion Molecules Research
• Gene Expression Regulation, Neoplastic
• Gene Ontology
• Gene Regulatory Networks
• Hippo pathway signaling and YAP/TAZ
• Lymphocytes, Tumor-Infiltrating
• Microsatellite Instability

Identifiers and source

Literature Corpus work

2e8298c7-7c22-5ad1-9dbc-35dc81157593

DOI

10.1101/2024.06.28.601055