Article

Synergistic Effects of Cepharanthine and Amphotericin B Against Candida albicans by Targeting PMP3-Mediated Sphingolipid Biosynthesis and Membrane Disruption

2026-05-26

Abstract excerpt

<title>Abstract</title> Oral candidiasis, primarily caused by <italic>Candida albicans</italic> , poses challenges in current antifungal therapy because of limited number of drugs, increased pathogen resistance, and notable toxicity associated with existing medications. Combination therapy is crucial for optimizing treatment outcomes. In this study, cepharanthine (CEP) was explored as an adjunct to amphote...

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Literature Corpus work: 2deefd55-fe3c-533a-a93a-cb8d871620df
DOI: 10.21203/rs.3.rs-9714769/v1

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Synergistic Effects of Cepharanthine and Amphotericin B Against Candida albicans by Targeting PMP3-Mediated Sphingolipid Biosynthesis and Membrane DisruptionDOI 10.21203/rs.3.rs-9714769/v1Read

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