Article

Stalled CARs: Mechanisms of Resistance to CAR T Cell Therapies

2023-04-11

Abstract excerpt

Chimeric antigen receptor (CAR) T cell therapy has emerged as a new opportunity for cancer treatment; however, resistance can occur due to intrinsic (T cells), extrinsic (tumors), or acquired (tumors) factors. In many cases, the knowledge of these mechanisms comes from clinical observations of patients treated with CAR T cells. In addition, the structure of the CAR molecule and the manufacturing process can impact...

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Literature Corpus work: 2dac89dc-6f0d-5d9b-a03a-129c9526a8b1
DOI: 10.1146/annurev-cancerbio-061421-012235

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