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Article

The G127V variant of the prion protein interferes with dimer formation in vitro but not in cellulo.

Scientific reports - 4 Feb 2021

Sangeetham Sudheer Babu, Engelke Anna Dorothee, Fodor Elfrieda, Krausz Sarah Laura, Tatzelt Jörg, Welker Ervin

Abstract excerpt

Scrapie prion, PrPSc, formation is the central event of all types of transmissible spongiform encephalopathies (TSEs), while the pathway with possible intermediates and their mechanism of formation from the normal isoform of prion (PrP), remains not fully understood. Recently, the G127V variant of the human PrP is reported to render the protein refractory to transmission of TSEs, via a yet unknown mechanism....

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Identifiers

PMID: 33542378
DOI: 10.1038/s41598-021-82647-w
PMCID: PMC7862613

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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