Article

Beyond Neurodegeneration: White Matter Vacuolation as a Primary Myelin Defect

2026-07-30

Abstract excerpt

Spongiform degeneration, or status spongiosis, is characterized by vacuoles within the central nervous system. It appears in numerous neurological diseases, including trans-missible spongiform encephalopathies, mitochondrial disorders, and lysosomal storage diseases. Traditionally considered secondary to neurodegeneration, vacuolar changes frequently involve white matter and form within the myelin sheath. This rev...

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Literature Corpus work: 2d3dc315-471e-5f89-9877-2961c1fa4151
DOI: 10.20944/preprints202607.2244.v1

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